LESIEUR Sylviane
:
Sylviane.lesieur[a]u-psud.fr
:
+33.1 46 83 53 49
:
+33.1 46 83 53 12
Bureau :
Tour B / 420
CV
Sylviane LESIEUR est Directeur de Recherche CNRS (Institut de Chimie, section 11), Ingénieur de l’Ecole Nationale Supérieure des Industries Chimiques (ENSIC, INPL Nancy), diplômée d’études approfondies (DEA) en « Sciences pour les Industries Chimiques, option Physico-Chimie Macromoléculaire et Génie Chimique des Systèmes Vivants » (INPL, Nancy), elle est titulaire d’un Doctorat d’Etat ès Sciences Physiques de l'Université Pierre et Marie Curie (Paris VI).
Responsable de l’équipe Physico-Chimie des Systèmes Polyphasés de l’IGPS depuis 2007, ses activités de recherches portent sur les systèmes formés par les lipides d’origine naturelle ou synthétique et autres composés amphiphiles, seuls ou en présence de substances hôtes, l’étude de leurs mécanismes de formation et de leurs relations structure-propriétés, leur utilisation pour modéliser les membranes et interfaces biologiques ainsi que leur mise en oeuvre pour le développement de nano- ou microtechnologies pour des applications biomédicales, pharmaceutiques ou cosmétiques.
Sylviane LESIEUR is CNRS Research Director (Institute of Chemistry, section 11), she graduated from the engineering school “Ecole Nationale Supérieure des Industries Chimiques (ENSIC, INPL Nancy)” and from a Master of advanced studies in “Sciences for the Chemical Industries, option Macromolecular Chemistry and Chemical Engineering of Living Systems” before holding a “Doctorat d’Etat” in Physical Sciences at University Pierre et Marie Curie (Paris VI).
Leader of the research team “Physico-Chimie des Systèmes Polyphasés” in Galien Paris-Sud Institute (IGPS, UMR CNRS 8612), she focuses her research activities on systems composed of natural or synthetic lipids and other amphiphilic compounds, alone or in association with guest substances, the study of their formation mechanisms and structure-property relationships, their use as models of biological membranes and interfaces as well as the development of nano- and microtechnologies for applications in biomedical, pharmaceutical and cosmetic fields.
.
Mots clés
Lipides, caractérisation structurale multi-échelle, diagrammes de phase, matériaux lipidiques, assemblages supramoléculaires, structures nanométriques fonctionnelles, biophysique des membranes biologiques, transition micelle-vésicule, imagerie biomédicale, colloïdes lipidiques, technologie des liposomes
Lipids, multiscale structural characterization, phase behaviour, lipid materials, supramolecular assemblies, functional nanoscale structures, biophysics of biological membranes, micelle-to-vesicle transition, biomedical imaging, lipid-based colloids, liposome technology
Publications Majeures sur les 20 dernières années
- New sterically stabilized vesicles based on nonionic surfactant, cholesterol, and poly(ethylene glycol)-cholesterol conjugates. S. Beugin, K. Edwards, G. Karlsson, M. Ollivon, S. Lesieur. Biophysical Journal.1998,74:3198-3210.
- Phase behavior of mixed aqueous dispersions of DPPC and dodecyl glycosides: aggregation states implicated in the micelle-to-vesicle transition. B. Carion-Taravella, J. Chopineau, M. Ollivon, S. Lesieur. Langmuir1998,14(14):3767-3777.
- Enzyme-mediated formation of vesicles from DPPC-dodecyl maltoside mixed micelles. B. Carion-Taravella, S. Lesieur, M. Ollivon, J. Chopineau. J. Am. Chem. Soc.1998120(41):10588-10595
- Phase behavior of fully hydrated DMPC-amphiphilic cyclodextrin systems. S. Lesieur, D. Charon, P. Lesieur, C. Ringard-Lefebvre, V. Muguet, D. Duchêne, D. Wouessidjewe. Chem. Phys. Lipids.2000,106:127-144
- Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging. M.S. Martina, J.P. Fortin, C. Ménager, O. Clément, G. Barratt, F. Gazeau, V. Cabuil, S. Lesieur. J. Am. Chem. Soc.2005,127:10676-10685
- Inclusion complex of n-octyl-?-D-glucopyranoside and ?-cyclodextrin in aqueous solution: thermodynamic and structural characterization. V. Bernat, C. Ringard-Lefebvre, G. Le Bas, B. Perly, F. Dedjaïni-Pilard, S. Lesieur. Langmuir.2008,24:3140-3149
- Anti-estrogen-loaded superparamagnetic liposomes for intracellular magnetic targeting and treatment of breast cancer tumors.V. Plassat, C. Wilhelm, V. Marsaud, C. Ménager, F. Gazeau, J.M. Renoir, S. Lesieur. Adv. Funct. Mat.2011,21:83-92
- Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: analysis of drug and water diffusion processes with X-ray-based diffraction methods. P. Pivette, V. Faivre, L. Mancini, C. Gueutin, G. Daste, M. Ollivon, S. Lesieur. J. Controlled Release.2012,158(3):393-402
- A highly hydrated alpha-cyclodextrin/1-undecanol inclusion complex : crystal structure and hydrogen-bond network from high-resolution neutron diffraction at 20 K. D. Gallois-Montbrun, G. Le Bas, S. Mason, T. Prangé, S. Lesieur. Acta Crystallographica B.2013,69:2014-227
- Multicompartment lipid cubic nanoparticles with high protein upload: millisecond dynamics of formation.B. Angelov, A. Angelova, S.K. Filipov, M. Dreschler, P. Stepanek, S. Lesieur. ACSNano.2014,8(5):5216-5226
- Entrapment of a neutral Tm(III)-based complex with two inner-sphere coordinated water molecules into PEG-stabilized vesicles : towards an alternative strategy to develop high-performance LipoCEST contrast agents for MR imaging. B. Chahid, L. Vander Elst, J. Flamment, C. Medina, M. Port, R. Muller, S. Lesieur. J. Contrast Media and Molecular Imaging.2014,9:391-399
- Superparamagnetic liposomes for MRI monitoring and external magnetic field-induced selective targeting of malignant brain tumors. H. Marie, L. Lemaire, F. Franconi, S. Lajnef, Y.M. Frapart, V. Nicolas, G. Frébourg, M.Trichet, C. Ménager, S. Lesieur. Adv. Funct. Mater.2015,25:1258-1269
- Mechanical induction of the tumorigenic b-catenin pathway by tumour growth pressure. M. E. Fernandez-Sanchez, S. Barbier, J. Whitehead, G. Bealle, A. Michel , H. Latorre-Ossa, C. Rey, L. Fouassier, A. Claperon, L. Brullé, E. Girard, N. Servant, T. Rio-Frio, H. Marie, S. Lesieur, C. Housset, J.L. Gennisson, M. Tanter, C. Ménager, S. Fre, S. Robine, E. Farge. Nature. 2015,523:92-95
- Mesoporous : Self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances. L. Zerkoune, S. Lesieur, J.L. Putaux, L. Choisnard, A. Gèze, D. Wouessidjewe, B. Angelov, C. Vebert-Nardin, J. Doutch, A. Angelova. Soft Matter. 2016,12:7539-7550
- Mechanical induction of the tumorigenic b-catenin pathway by tumour growth pressure Scalable Process to produce Lipid-based Compartmented Janus nanoparticles with pharmaceutically approved excipients. T. Truong-Cong, E. Millart, C.T.L. Le Tuyet, H. Amenitsch, G. Frebourg, S. Lesieur, V. Faivre. Nanoscale. 2018,10:3654-3662