Nouvelles stratégies de ciblage appliquées au cancer
Publications majeures
Gao P, Nicolas J, Ha-Duong T “Supramolecular Organization of Polymer Prodrug Nanoparticles Revealed by Coarse-Grained Simulations”. J. Am. Chem. Soc. 2021, 143, 17412
Boutary S, Caillaud M, El Madani M, Vallat J-M, Loisel-Duwattez J, Rouyer A, Richard L, Gracia C, Urbinati G, Desmaële D, Echaniz-Laguna A, Adams D, Couvreur P, Schumacher M, Massaad C, Massaad-Massade L; Squalenoyl siRNA PMP22 nanoparticles, a potent therapy for Charcot-Marie-Tooth disease type 1A. Nature Commun. Biol. 2021, 4, 317
Pautu V, Zaho H, Mielcarek A, Stella B, Balasso A, Couvreur P, Serre C, Mura S. When drug nanocarriers miss their target: extracellular diffusion and cell uptake are not enough to be effective. Biomater. Sci. 2021, 9, 5407
Habas K, Soldevila-Barreda J J, Azmanova M, Rafols L, Pitto-Barry A, Anderson D, Barry N P E. “Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals”. ChemMedChem 2021, 16, 624-629
Ho D-K, Murgia X, De Rossi C, Chrismann R, Hüfner de Mello Martins AG, Koch M, Andreas A, Herrmann J, Müller R, Empting M, Hartmann RW, Desmaele D, Loretz B, Couvreur P, C-M Lehr “Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and Alkylquinolone Quorum Sensing Inhibitor to Eradicate P. aeruginosa Biofilm Infections”. Angew. Chem., Int. Ed. 2020, 59, 10292
Dormont F, Brusini R, Cailleau C, Reynaud F, Peramo A, Gendron A, Mougin J, Gaudin F, Varna M, Couvreur P "Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation” Science Adv. 2020, 6, eaaz5466
Mougin J, Yesylevskyy S0, Bourgaux C, Chapron D, Michel JP, Dosio F, Stella B, Ramseyer C, Couvreur P “Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin”. ACS Nano 2019, 13, 12870
Feng J, Lepetre-Mouelhi S, Gautier A, Mura S, Cailleau C, Coudore F, Hamon M, Couvreur P “A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine”. Science Advances 2019, 5, eaau5148
Peramo A., Dumas A. , Remita H., Benoît M., Yen-Nicolay S., Corre R., Louzada R. A., Dupuy, C., Pecnard S., Lambert B., Young Y., Desmaële D., Couvreur P. “Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles”. Chem. Commun. 2019, 55, 15121
Guégain E, Tran J, Deguettes Q, Nicolas J. “Degradable Polymer Prodrugs with Adjustable
Activity from Drug-Initiated Radical Ring-Opening Copolymerization”. Chem. Sci. 2018, DOI: 10.1039/c8sc02256a
Lazzari G, Nicolas V, Matsusaki M, Akashi M, Couvreur P, Mura S.
“Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic
pancreatic tumor complexity.” Acta Biomate. 2018, 78, 296
Vinciguerra D, Denis S, Mougin J, Jacobs M, Guillaneuf Y, Mura S, Couvreur P, Nicolas J.
“A Facile Route to Heterotelechelic Polymer Prodrug Nanoparticles
for Imaging, Drug Delivery and Combination Therapy”. J. Control. Release 2018, DOI: 10.1016/j.jconrel.2018.08.013
Sobot D, Mura S, Rouquette M, Vulosavljevic B, Cayre F, Buchy E, Pieters G, Garcia Argote S,
Windbergs M, Desmaële D, Couvreur P. “Conjugation of squalene to
gemcitabine as unique approach exploitins endogenous lipoproteins for drug
delivery”. Mol. Ther. 2017, 25, 1596
Tardy A, Honoré JC, Tran J, Siri D, Delplace V, Bataille I, Letourneur D,
Perrier J, Nicoletti S, Maresca M, Lefay C, Gigmes D, Nicolas J, Guillaneuf Y.
“Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile
Platform to Design Functional Polyesters.” Angew. Chem., Int. Ed. 2017, 56, 16515.
Kotelevets L, Chastre E, Caron J, Mougin J, Bastian G, Pineau A, Walker F,
Lehy T, Desmaële D, Couvreur P. “A squalene-based nanomedicine for oral treatment of
colon cancer”. Cancer Res. 2017, 77, 2964
Sobot D, Mura S, Yesylevskyy SO, Dalbin I, Cayre F, Bort G, Mougin J,
Desmaële D, Lepetre Mouelhi S, Pieters G, Andreiuk B, Klymchenfo AS,
Paul JL, Ramseyer C, Couvreur P. “Conjugation of squalene to gemcitabine as unique
approach exploiting endogenous lipoproteins for drug delivery”. Nature Commun. 2017, 8, 15678
Simon-Yarza T, Gimenez-Marques M, Mrimi R, Mielcarek A, Gref A, Horcajada P,
Serre C, Couvreur P. “Smart metal-organic-framework nanomaterial for lung targeting”.
Angew. Chem., Int. Ed. 2017, 56, 15565
Bao Y, Boissenot T, Guégain E, Desmaële D, Mura S, Couvreur P, Nicolas J.
"Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with
Tuneable Drug Delivery Properties”. Chem. Mater. 2016, 28, 6266
Delplace V, Nicolas J “Degradable Vinyl Polymers for Biomedical Applications” Nature Chem. 2015, 7, 771
Romero-Canelón I, Phoenix B, Pitto-Barry A, Tran J, Soldevila-Barreda J J, Kirby N, Green S, Sadler P J, Barry N P E. “Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT)”. J. Organomet. Chem. 2015, 796, 17-25.
Barry N P E, Pitto-Barry A, Romero-Canelón I, Tran J, Soldevila-Barreda J J, Hands-Portman I, Smith C J, Kirby N, Dove A P, O'Reilly R K, Sadler P J. “Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity”. Faraday Discussions, 2015, 175, 229-240.
Pitto-Barry A, Barry N P E, Russo V, Heinrich B, Donnio B, Therrien B, Deschenaux R. “Designing supramolecular liquid-crystalline hybrids from pyrenyl-containing dendrimers and arene ruthenium metallacycles”. J. Am. Chem. Soc. 2014, 136, 50, 17616–17625
Maksimenko A, Dosio F, Mougin J, Ferrero A, Wack S, Harivardhan Reddy L,
Weyn A, Lepeltier E, Bourgaux C, Stella B, Cattel L, Couvreur P.
“Squalenoylated Doxorubicin: A New Long Circulating and Non Pegylated Anticancer
Nanomedicine”. Proceeding Nat. Acad. Sci., USA 2014 111, E217
Mackiewicz, N, Nicolas, J, Hanke N, Noiray M, Mougin J, Daveu C, Lakkireddy Reddy L,
Bazile D, Couvreur P. “Precise engineering
of multifunctional PEGylated polyester nanoparticles for cancer cell targeting and imaging”.
Chem. Mater. 2014, 26, 1834
Maksimenko A, Alami M, Zouhiri F, Brion JD, Pruvost A, Mougin J, Hamze A,
Boissenot T, Provot O, Desmaële D, Couvreur P. “Therapeutic modalities of squalenoyl
nanocomposites in colon cancer: an ongoing search for improved efficacy”. ACS Nano 2014, 8, 2018
Gaudin A, Yemisci M, Eroglu H, Lepêtre-Mouelhi S, Turkoglu OF, Donmez-Demir B, Caban S,
Sargon MF, Garcia-Argote S, Pieters G, Loreau O, Rousseau B, Tagit O, Hildebrandt N, Le Dantec Y, Mougin J, Valetti S, Chacun H,
Nicolas V, Desmaële D, Andrieux K, Capan Y, Dalkara T, Couvreur P. “Squalenoyl Adenosine
Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury”. Nature Nano. 2014, 9, 1054
Mura S, Nicolas J, Couvreur P. “Stimuli-responsive nanocarriers for drug delivery”.
Nature Materials 2013, 12, 991-1003.
Harrisson S, Nicolas J, Maksimenko A, Duc Trung B, Mougin J, Couvreur P.
“Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles
Prepared by Living Radical Polymerization”. Angew. Chem., Int. Ed. 2013, 52, 1678
Le Droumaguet B, Nicolas J, Brambilla D, Mura S, Maksimenko A, Salvati E, De Kimpe L,
Zona C, Airoldi C, Canovi M, Gobbi M, Noiray M, La Ferla B, Nicotra F, Scheper W, Flores O,
Masserini M, Andrieux K, Couvreur P. « Versatile and Efficient Targeting Using a Single Nanoparticulate Platform:
Application to Cancer and Alzheimer’s Disease » ACS Nano 2012, 6, 5866-5879.